Phospholipids—The Preferred Carrier to the Brain

 July 10, 2020

Why is Accentrate® Brain Ready® nutrition? Why do we say we have Tissue-Targeted® EPA and DHA?

Accentrate® has been formulated with EPA and DHA in phospholipid form, which is the preferred carried to the brain.

The brain contains very high concentration of docosahexaenoic acid (DHA), which is essential for the normal development and function of the brain.[1] EPA and DHA protect against multiple metabolic and neurologic disorders.[2]

“DHA cannot be synthesized de novo and must be obtained directly in the diet or via the conversion of shorter chain essential n-3 PUFA, including α -linolenic acid, to DHA predominately in the liver. As the brain synthesis of DHA is very low, it is generally agreed that the brain is supplied with DHA from the plasma.”[3]

Omega-3 fatty acids exist in the body in three forms generally, the triglyceride form, the free fatty acid form, and the phospholipid form. Substantial research has attempted to determine which forms are best absorbed. Further research has gone to determine which forms are best absorbed in the brain.

One study that compared the absorption of EPA in phospholipid form to free fatty acid for showed that EPA in phospholipid form, but not free EPA, increased brain DHA 2-fold. Free EPA increased EPA in adipose tissue, and both supplements increased EPA and DHA in the liver and heart.[4] Only EPA in phospholipid form increased EPA and DHA in the retina, and expression of brain-derived neurotrophic factor, cyclic AMP response element binding protein, and 5-hydroxy tryptamine (serotonin) receptor 1A in the brain. These novel results show that brain EPA can be increased through diet.[5]

The results show that DHA from triglyceride, which is released as free DHA during digestion and is was incorporated preferentially into adipose (fat) tissue and heart but not into brain. In contrast, phospholipid DHA increased brain DHA by up to 100%, but had no effect on adipose tissue.[6]

Accentrate® doesn’t need high doses of EPA and DHA like fish oil supplements, because Accentrate provides EPA and DHA in the form EPA and DHA is already in the brain.

Here we see that EPA and DHA from fish oil, or in triglyceride form (TAG) goes through substantial metabolism, and the omega-3s typically end up in adipose tissue, heart, or muscle, and little makes it to the brain. DHA in the phospholipid form, is Targeted to the brain (Tissue).

References:

[1] Sugasini, et al, “Enrichment of brain docosahexaenoic acid (DHA) is highly dependent upon the molecular carrier of dietary DHA: lysophosphatidylcholine is more efficient than either phosphatidylcholine or triacylglycerol,” Journal of Nutritional Biochemistry, 74 (2019) 108231.

[2] Yalagala, et al., “Dietary lysophosphatidylcholine-EPA enriches both EPA and DHA in the brain: potential treatment for depression.” Journal of Lipid Research, Volume 60, 2019, p 566-577.

[3] Chen, C. T. et al. “Plasma non-esterified docosahexaenoic acid is the major pool supplying the brain. Sci. Rep. 5, 15791.

[4] Yalagala, et al., “Dietary lysophosphatidylcholine-EPA enriches both EPA and DHA in the brain: potential treatment for depression.” Journal of Lipid Research, Volume 60, 2019, p 566-577.

[5] Yalagala, et al., “Dietary lysophosphatidylcholine-EPA enriches both EPA and DHA in the brain: potential treatment for depression.” Journal of Lipid Research, Volume 60, 2019, p 566-577.

[6] Sugasini, et al, “Enrichment of brain docosahexaenoic acid (DHA) is highly dependent upon the molecular carrier of dietary DHA: lysophosphatidylcholine is more efficient than either phosphatidylcholine or triacylglycerol,” Journal of Nutritional Biochemistry, 74 (2019) 108231.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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Alissa

We are so pleased with this product! It has really helped my son!

Tammy

I am so thankful for this product. We were using Vayarin and then they stopped shipping to the US. This product works the same as the other one. We are so thankful because it has been life changing for our son.

Oliva

My husband and I see an improvement in our son’s ability to focus. We definitely want to continue Mark on his Accentrate110, and our confidence in Fenix is very high. We feel like you really care about us, our son, and your service.

Jill

I cannot even begin to tell you how thankful my family is for Accentrate. My 8yo stopped taking it for 6 weeks and went from homework taking 15 minutes to taking 3 hours. 4 days back on it and he was back to normal. Ty for an amazing product that is keeping my guy balanced, and focused in school and at home!

Mariano

I just wanted to thank you and your company for your commitment with your patients. Fourth months ago I wasn't able to receive your product directly in Puerto Rico and today I can. This is how your company differentiate from others, hearing the voice of your customer.

Helen

We were Vayarin users until they stopped making it. We tried a few products that were supposed to be comparable, and they did not work for us. Then we found Accentrate. Vayarin worked perfectly for her, and so does Accentrate. We are very thankful for this product and customer service went beyond our expectations. Thank you!

Pelac

Hello ,we used to use Vayarin for more than a year, than stopped produced it. This is our third mounth we use Accentrate. It’s even better than Vayarin! My son is 6 years old, the attention is now better. He speaks better too.

Tammie

We are starting month 3 and we have seen lots of positive changes with emotional balance...she is easier to compromise with and a lot quicker to calm self. She has been helping around the house and helping with younger brother (hw with 6 yr old)…looking forward to many more positives…thank you.

April

My 8 year old has struggles with focus. Sometimes he has a hard time following conversations and multi step instructions. He started Accentrate more than 2 months ago. His only comment was about the fishy burps! But now he takes them with a small snack and that isn’t a problem anymore. The main difference that we have seen is that he is having an easier time winding down at bedtime. He was having regular meltdowns but they seem to be fewer and farther between. I’m looking forward to seeing if there are any differences once school starts back up since we started at he very end of last school year.

Lori

It has truly made a difference in our son’s life! We are so thankful to have it!

Stephanie

We are nearing the end of our first 45 days of Accentrate for our two boys, and we are pleased to say that we did not skip a beat as we took our last Vayarin one day and we had the Accentrate ready for the next morning. It has been such a seamless transition-our boys (ages 10 and 11) have been able to remain focused and calm. My kids even enjoy taking Accentrate so much more than Vayarin. They would fight us every morning when they took Vayarin saying it “tasted fishy”. Accentrate has NO taste, it is only one pill versus the two pills of Vayarin, and it slides down so easily. The kids just think of it as an extra multi-vitamin because it is filled with so many extra nutrients. They actually take Accentrate willingly!

Kassie J

I used to ask my son how he was feeling and he’d say, “it’s hard to explain mom, cause I don’t really know how I feel.” We use to call it being zombified. He has now been taking Accentrate for 3 months and the difference in the way he feels, acts, eats is something I prayed for every single day. Accentrate gives my child the vitamins that his brain and body needs. I am amazed at the improvement of his overall health and I have Accentrate to thank. Thank you, you’ve given my son his “life” back! I strongly recommend Accentrate to any parent.

Vincent

I just wanted thank you guys for such an awesome product. We’ve been giving my son Accentrate for a little over a month and a half and we are really starting to see a big change in my son. Before, he could not focus at school, he used to get easily annoyed and bored. Also, he could not deal with transitions, fidgeting, and making noises and whining. He always wanted to do good in school, but physically and mentally he was having a difficult time. The school he goes to color codes a kid’s day by his behavior. Red is bad, yellow is ok, green is a good day, and purple is an awesome day. Everyday he would get either a yellow or red, with a green intermittently, forget about him bringing home a purple. Fast forward to now, and he brings home at least one purple during the week, and almost green everyday. He’s only had maybe 3 or 4 yellows since he has been on it. This week he has earned student of the week, the first time ever in his life. I used to stress out everyday because I knew when I picked up my son, I would have to hear how he had a terrible day. Well not anymore. Accentrate has helped my son and I, tremendously. I hope my story can help other parents. I started to research different alternatives and noticed some good reviews on Accentrate, that’s when I gave it a try. I can only imagine it will get even better with time. You definitely have a returning customer! Again, I couldn’t thank you guys enough.

Melissa

My daughter just started Accentrate a week ago, she is 13, about 105 pounds, 5 feet. I have been having her take one in the morning and at night more to get it built up into her system. I must say that I can definitely tell that all of her spark plugs are beginning to fire. I’m so glad to find something that works for her.

Mandy

We are on month 4 of Accentrate and my 11 year old girl seems so much better!

M Tucker

We first tried Vayarin for three or so months. We didn’t notice any improvements. Then we found Accentrate, which has the phospholipid omega-3s that Vayarin has, but also has many other vitamins, minerals, and cofactors, and it was cheaper so we thought we’d give it a try. He’s been on it for more than six months. At his parent teacher conference and his report card, his teachers have said his attention and focus is improved. He’s still energetic at home and when we go out. But he can sit and read. He can sit in class and pay attention.

Linda W

My son has been steadily improving with his behavior after 3 months on Accentrate. He has had far less episodes at home and at school. He went from failing in all subjects except gym and art, to passing all but one subject, which is reading.

Kendra O.

I’ve spent at least a couple hundred dollars on different vitamins but they either tasted gross, too chewy or just couldn’t stomach them. I was introduced to Accentrate recently and thought we’d give it a try with our kids. They’ve been on it pretty regularly since summer and they say it helps them. I think it’s a solid product just by doing my own research on what vitamins are beneficial for children struggling with focus. This is the only vitamin that I have found that combines everything I was looking for. My kids range in age from 8-12.

Jen P

My son has been taking Accentrate for the last four months. We’ve noticed improvement! The first benefits we noticed were calming in his behavior. He had fewer mood outbursts. He still did, but to a noticeably lessor extent. We have found recently, that we do not have to hassle him to sit and do his homework or reading either.

Corrie

I actually purchased the 3-month supply for both me and my son, so we’re almost through the whole package. Hence, the additional order placed this week. I wanted us both to try it first for a month or so to determine if it’s something we’d like to keep taking. I have noticed some improvements in both of us – specifically in our ability to remember things. That’s been a big issue for both of us – something I’ve often referred to as being “scatter-brained.” I’ve noticed more changes in my son, so I think it’s impacting him more quickly than me, but I’ve seen enough to want to continue. As for the product itself, we love the packaging with the dates - it can be difficult to remember if we’ve taken medicine from day to day, so have a package that helps us manage that is so helpful!

Cherie M

My son has been on Accentrate since June 2018. He is doing very well. The first thing we noticed was that he had significantly calmed down after a week of taking Accentrate. We didn’t notice improvements in focus or attention until later in September, but this might also be because he wasn’t in school in June or July. We’ve continually reordered because we feel it helps. It’s nice to take one pill instead of multiple supplements.

Cherie M

The first thing we noticed was that he had significantly calmed down after a week of taking Accentrate. We’ve continually reordered because we feel it helps. It’s nice to take one pill instead of multiple supplements.

Twinkie Mom

Accentrate has been very successful for our family. We started our son on it roughly 2 months ago and have noticed an improvement in his behaviour and his focus. Conversations with him are more enjoyable and he seems to be able to keep himself settled a bit more. We like that this product is healthy and that it feeds the brain everything it needs. For this reason, we’ve decided to put our other child on this supplement as well. A few weeks in, we coupled Accentrate with a gluten free and dairy free diet and noticed even greater improvements.

Nikki

My son just finished up the three-month supply we bought and we are re-ordering. While this didn’t help him focus and concentrate like the medication did, there was enough improvement that I’d rather him be on a natural product than on an addictive substance with side effects. His teachers say that he is manageable and are supportive of our decision.

Rebecca

We saw that fish oils, magnesium, multi-vitamins might help. And they did. But it was always hard having her take three different pills. This product is great because it’s one small pill with all these nutrients that we were already comfortable with. She didn’t like the fish oil pill, and said it was very fishy. This doesn’t taste fishy to her at all. The tracking component of the packaging is just brilliant. It’s helped us more than once notice we missed a day.

Phospholipids—The Preferred Carrier to the Brain

All Products

Accentrate®

Accentrate®Gummy

MZI™ Kids

Accentrate110®

Real Reviews from Real Customers 25 Reviews

Real Reviews from Real Customers
25 Reviews