For Medical Practitioners

How Accentrate® works

Accentrate® provide lipid nutritional support essential for healthy mood and cognitive function. It contains EPA and DHA in the phospholipid form as well as a combination of vitams, which the body uses to support proper regulation of neurotransmitters needed for optimal cognition, including memory, attention, and focus.

Learn more about Fenix Assist

This program is designed to encourage compliance with your patients and help them remember to order their supplements.

Please download the form, check mark the product you wish your patient to begin on, enter provider details and patient information, and then email the completed form to [email protected].

A representative from our company will contact your patient as directed within 48 hours to help them order the recommended product.

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The research behind lipid imbalances

The u-3 polyunsaturated fatty acid (PUFA) docosahexaenoic acid (DHA) and, to a lesser extent, the u-6 PUFA arachidonic acid (AA) constitute a large proportion of the lipid in the brain. The u-3 PUFAs DHA and eicosapentaenoic acid (EPA) are involved in many aspects of brain function including cell growth, neural signaling, and gene expression. [1]

Omega-3 PUFAs are thought to play an important role in cell membrane elasticity and myelination and may thus affect neural signal transduction. Animal studies indicated that omega-3 PUFA deficiency, and specifically DHA deficiency, results in decreased neuron size in rats that were raised on a DHA-deficient diet. Furthermore, both dopaminergic and serotonergic neurotransmission have been shown to be reduced in rats on an omega-3 PUFA-deficient diet, with marked effects in the frontal cortex. [2]

More specifically, lower frontal cortical omega-3 PUFA status correlated with impulsive behavior in rats. Interestingly enough, a vast body of human literature has implied neurotransmitter dysfunction and impairments in cognitive control for those suffering with lack of focus and emotional balance.

It’s also been shown that individuals with a lack of focus and emotional balance are more likely to have low levels of certain lipids, specifically certain omega-3 fatty acids. The imbalances in lipid metabolism that may occur are associated with increased oxidative stress, higher rates of lipid degradation, and decreased synthesis of phospholipids containing omega-3 fatty acids. Reduced levels of phospholipid-EPA and phospholipid-DHA affect membrane structure and function.

Accentrate® promotes optimal neurotransmitter regulation

Signal transduction and receptor signaling are major membrane functions which may be influenced by membrane stability and fluidity. Lower concentration of omega-3 LCPUFA in neuronal tissue has been speculated to lead to lower serotonin levels at critical periods of neurodevelopment and may result in a cascade of suboptimal development of neurotransmitter systems limiting regulation of the limbic system by the frontal cortex, thus explaining the association to oppositional behavior.” [5]

Backed by scientific research

Accentrate® was specifically formulated to include ingredients backed by scientific research

However, in recent years there has been a growing interest in nutrituonal supplements to provide an option for parents and clinicians looking for alternative or additive assistance.

Accentrate® contains premium ingredients that are not often found in an over-the-counter multivitamin. The ingredients are the active, bioavailable forms that cross the blood-brain barrier, which is why we call it Brain Ready Nutrition. Each ingredient is backed by the scientific literature.

See a complete list of all referenced studies

Accentrate® is More

It has been reported that “single-nutrient studies have yielded only modest findings, whereas broader interventions may be more promising… A consideration of some of the ingredients and the role they play in brain metabolism highlights the importance of the broad array of nutrients and may help explain the non-specific effects the nutrients appear to have on psychiatric symptoms”.

Accentrate® helps support focus, memory, attention, and emotional balance. Accentrate® may be combined with a proper diet, behavioral therapy, and medication (if needed) as recommended by a medical practitioner. Children will have the best possible tool set to support focus and emotional balance effectively.

Tissue-Targeted EPA and DHA

Tissue-Targeted™ EPA and DHA are omega-3 fatty acids conjugated to a phospholipid (PL).

EPA and DHA in this form, unlike fish oil, readily bypass the blood brain barrier and are absorbed by brain tissue through Lyso-phosphatidylcholine.

“Omega-3 fatty acids play a very important role during brain development, partly through their regulation of the serotonin system. Reduced intake of EPA and DHA during neurodevelopment results in decreased serotonin synthesis, storage, release, and receptor function.”

It has been reported that the developmental difficulties associated with a lack of focus and emotional balance have a neurological basis and might be related to low levels of omega-3 polyunsaturated fatty acids (PUFA).

It has been proposed that EPA regulates serotonin release and that this omega-3 fatty acid modulates serotonin function through regulation of serotonin release in the presynaptic neuron.

It has also been proposed that DHA regulates serotonin receptor function and that omega-3 fatty acids modulate the serotonin system through DHA mediated regulation of serotonin receptor function, which depends on cell membrane fluidity. DHA is the most abundant fatty acid in the brain, making up 30% of the fatty acid content. Cell membrane fluidity depends on the amount of omega-3 fatty acids in the membrane and phospholipids, which increase membrane fluidity. DHA composition in the lipid membrane is necessary for adequate membrane fluidity (167–170).


Riboflavin, is Vitamin B2, and is a coenzyme used in the metabolism of dopamine and is a co-factor in the metabolism of essential fatty acids in brain lipids. Riboflavin derivatives also have direct antioxidant properties and increase endogenous antioxidant status as essential cofactors in the glutathione redox cycle.

These statements have not been evaluated by the Food and Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease.


L-methylfolate is the bioavailable form of folic acid and crosses the blood brain barrier. L-methylfolate regenerates tetrahydrobiopterin, which is essential for neurotransmitter formation. L-methylfolate is necessary for proper regulation of neurotransmitters, which supports mood, attention, and memory.

Vitamin B6/B12

“Vitamin B6 (pyridoxal 5’-phosphate) acts as a cofactor for the synthesis of gamma-aminobutyric acid, serotonin and dopamine.”  It has been reported that administration of Vitamin B6, Vitamin B12, and folate “might contribute to the positive effects … given their role in the regulation of homocysteine metabolism, mood, and neurotransmitter synthesis.

Vitamin D3

Vitamin D3 regulates serotonin. An underlying mechanism has been reported that describes how Vitamin D3 hormone appears to control 900 genes and is a key regulator of brain serotonin synthesis.

It has been reported that Vitamin D3 supplementation has been shown to support focus in children and adults.

These statements have not been evaluated by the Food and Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease.

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