Tissue-Targeted™ EPA and DHA are omega-3 fatty acids conjugated to a phospholipid (PL).
EPA and DHA in this form, unlike fish oil, readily bypass the blood brain barrier and are absorbed by brain tissue through Lyso-phosphatidylcholine.
“Omega-3 fatty acids play a very important role during brain development, partly through their regulation of the serotonin system. Reduced intake of EPA and DHA during neurodevelopment results in decreased serotonin synthesis, storage, release, and receptor function.”
It has been reported that the developmental difficulties associated with inattention and emotional dysregulation have a neurological basis and might be related to low levels of omega-3 polyunsaturated fatty acids (PUFA), and some evidence reports that children with inattention and emotional dysregulation and dyslexia may show improvements in symptoms following supplementations with omega-3 fatty acids.
It has been proposed that EPA regulates serotonin release and that this omega-3 fatty acid modulates serotonin function through regulation of serotonin release in the presynaptic neuron.
It has also been proposed that DHA regulates serotonin receptor function and that omega-3 fatty acids modulate the serotonin system through DHA mediated regulation of serotonin receptor function, which depends on cell membrane fluidity. DHA is the most abundant fatty acid in the brain, making up 30% of the fatty acid content. Cell membrane fluidity depends on the amount of omega-3 fatty acids in the membrane and phospholipids, which increase membrane fluidity. DHA composition in the lipid membrane is necessary for adequate membrane fluidity (167–170).
It has also been suggested that “increased u-3 PUFA intake can improve attention, literacy, and behavior problems in some children with inattention and emotional dysregulation.”